Cross-reactive memory

Re-Engaging Cross-Reactive Memory B Cells: The Influenza Puzzle

The emergence of a novel influenza A virus strain into humans poses a continuous public health threat. Vaccination is the most effective means of protection against influenza. The generation of memory B cells and long-lived plasma cells that can maintain protective levels of influenza-specific antibodies for protracted periods of time is the foundation for the success of such vaccines. Influenz...

Models of immune memory: on the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory.

There has been much debate on the contribution of processes such as the persistence of antigens, cross-reactive stimulation, homeostasis, competition between different lineages of lymphocytes, and the rate of cell turnover on the duration of immune memory and the maintenance of the immune repertoire. We use simple mathematical models to investigate the contributions of these various processes t...

Cross-reactive chemical sensor arrays.

Cross - Reactive Idiotopes in Balb

The existence of a functional idiotypic network was postulated by Jerne (1) nearly one decade ago. Many experiments do indeed prove the feasibility of idiotypic manipulations of the immune system (see reference 2 for a review of this topic). It still remains to be established however, that idiotype-antiidiotype interactions play a major role in the ontogenesis of the immune system and that such...

Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors.

Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV. We have tracked the evolution of ZIKV-induced B cell responses in three DENV-experienced donors. The acute antibody (plasmablast) responses were characterized by relatively high somatic hypermutation and a bias toward DENV binding and n...